Organic Devices and Brain Organoids: The Quest for Next Generation Neuronal Interfacing

The advent of organic bioelectronics has introduced a deep change within the field of in vitro neural interfaces. In fact, the development of novel organic devices and materials deeply broadened the plethora of possible solutions for the development of innovative electrophysiological tools. At the same time, neural in vitro interfaces are evolving toward the study of ever more refined brain organoids, which represent a very important, and long sought-out, change of paradigm in the field. We here present a flexible, multifunctional, and reference-less organic transistor-based device with tridimensional recording sites for in vitro electrophysiology, which can represent an interesting and convenient solution for brain-on-a-dish applications.