Single cultured cells can be genetically modified with a silicon Multi Electrode Array which can locally and transiently break down the cell membrane, allowing exogenous molecules to enter the cell. An accurate electrical model of the biochip-solution-cell system can be coupled to a statistical method in order to evaluate the probability of correctly detecting the presence (or absence) of a cell over a given electrode.
Using a cell manipulation biochip to investigate the adhesion characteristics of single mammalian cells
De Toni, Alessandro;Lorenzelli, Leandro
2008-01-01
Abstract
Single cultured cells can be genetically modified with a silicon Multi Electrode Array which can locally and transiently break down the cell membrane, allowing exogenous molecules to enter the cell. An accurate electrical model of the biochip-solution-cell system can be coupled to a statistical method in order to evaluate the probability of correctly detecting the presence (or absence) of a cell over a given electrode.File in questo prodotto:
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