Single cultured cells can be genetically modified with a silicon Multi Electrode Array which can locally and transiently break down the cell membrane, allowing exogenous molecules to enter the cell. An accurate electrical model of the biochip-solution-cell system can be coupled to a statistical method in order to evaluate the probability of correctly detecting the presence (or absence) of a cell over a given electrode.

Using a cell manipulation biochip to investigate the adhesion characteristics of single mammalian cells

De Toni, Alessandro;Lorenzelli, Leandro
2008

Abstract

Single cultured cells can be genetically modified with a silicon Multi Electrode Array which can locally and transiently break down the cell membrane, allowing exogenous molecules to enter the cell. An accurate electrical model of the biochip-solution-cell system can be coupled to a statistical method in order to evaluate the probability of correctly detecting the presence (or absence) of a cell over a given electrode.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11582/4093
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