In this work we present the development of a system intended for DNA label free detection, based on piezoresistive microcantilever arrays and dedicated readout ASIC. Detector design and microfabrication technologies have been optimised for detection sensitivity, providing an efficient direct electrical measurement of DNA hybridisation. Readout ASIC has been implemented using a 0.35μm CMOS technology to provide a high resolution and low noise readout of the sensors, by also providing the compensation of large offset in the detector response.
Design of a cantilever-based system for DNA detection
Adami, Andrea;Borghetti, Fausto;Massari, Nicola;Decarli, Massimiliano;Collini, Cristian;Lorenzelli, Leandro;Stoppa, David
2011-01-01
Abstract
In this work we present the development of a system intended for DNA label free detection, based on piezoresistive microcantilever arrays and dedicated readout ASIC. Detector design and microfabrication technologies have been optimised for detection sensitivity, providing an efficient direct electrical measurement of DNA hybridisation. Readout ASIC has been implemented using a 0.35μm CMOS technology to provide a high resolution and low noise readout of the sensors, by also providing the compensation of large offset in the detector response.File in questo prodotto:
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