We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.

Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution

Tessarolo, Francesco;
2013

Abstract

We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.
File in questo prodotto:
File Dimensione Formato  
2013 Parakhonskiy et al Dependence of submicron vaterite container release properties.pdf

non disponibili

Descrizione: Full paper
Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.44 MB
Formato Adobe PDF
1.44 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11582/308350
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
social impact