We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.
Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution
Tessarolo, Francesco;
2013-01-01
Abstract
We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.| File | Dimensione | Formato | |
|---|---|---|---|
|
2013 Parakhonskiy et al Dependence of submicron vaterite container release properties.pdf
non disponibili
Descrizione: Full paper
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
1.44 MB
Formato
Adobe PDF
|
1.44 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
