The effects of mitoxantrone (MITOX) (an anthracenedione derivative, that retains the antitumour efficacy of the anthracycline agents but has less associated cardiotoxicity) alone and combined with byperthermia (HT) have been analysed in vitro and in a human adenocarcinoma cell line and, zn vlvo, in a munne mammary adenocarcinoma. To overcome the side effects of systemic drug administration, we have begun to use temperature-sensitive liposomes. The release of the drug. when liposomes are heated, should result ina localised delivery of the drug
Effects of hyperthermia on free and encapsulated mitoxantrone: results from in vitro and in vivo experiments
Lunelli, Lorenzo;Pederzolli, Cecilia
1998-01-01
Abstract
The effects of mitoxantrone (MITOX) (an anthracenedione derivative, that retains the antitumour efficacy of the anthracycline agents but has less associated cardiotoxicity) alone and combined with byperthermia (HT) have been analysed in vitro and in a human adenocarcinoma cell line and, zn vlvo, in a munne mammary adenocarcinoma. To overcome the side effects of systemic drug administration, we have begun to use temperature-sensitive liposomes. The release of the drug. when liposomes are heated, should result ina localised delivery of the drugFile in questo prodotto:
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