The effects of mitoxantrone (MITOX) (an anthracenedione derivative, that retains the antitumour efficacy of the anthracycline agents but has less associated cardiotoxicity) alone and combined with byperthermia (HT) have been analysed in vitro and in a human adenocarcinoma cell line and, zn vlvo, in a munne mammary adenocarcinoma. To overcome the side effects of systemic drug administration, we have begun to use temperature-sensitive liposomes. The release of the drug. when liposomes are heated, should result ina localised delivery of the drug

Effects of hyperthermia on free and encapsulated mitoxantrone: results from in vitro and in vivo experiments

Lunelli, Lorenzo;Pederzolli, Cecilia
1998-01-01

Abstract

The effects of mitoxantrone (MITOX) (an anthracenedione derivative, that retains the antitumour efficacy of the anthracycline agents but has less associated cardiotoxicity) alone and combined with byperthermia (HT) have been analysed in vitro and in a human adenocarcinoma cell line and, zn vlvo, in a munne mammary adenocarcinoma. To overcome the side effects of systemic drug administration, we have begun to use temperature-sensitive liposomes. The release of the drug. when liposomes are heated, should result ina localised delivery of the drug
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11582/1600
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
social impact