Liposomes have been widely employed as carrier systems for anti-cancer drugs. These lipid systems tend to accumulate within organs of the reticuloendothelial system (RES) and also at disease sites, including tumours. As a result they offer the potential to modify both the pharmacokinetics and the biodistribution of encapsulated drug. Liposomes can also be designed to leak thir contents due to an increase of permeability at the temperature of the gel-liquid crystal phase transition. By this method both a selective increase of drug in tumour areas, and the positive interaction between hyperthermia and certain drugs, can be used to increase the tumour cell killing. In murine studies we have compared the plasma clearance and biodistribution by varying the formulation and size of liposomes following intraperitoneal administration
Plasma clearance and biodistribution of thermosensitive liposomes in tumor bearing mice
Pederzolli, Cecilia;Lunelli, Lorenzo;
1998-01-01
Abstract
Liposomes have been widely employed as carrier systems for anti-cancer drugs. These lipid systems tend to accumulate within organs of the reticuloendothelial system (RES) and also at disease sites, including tumours. As a result they offer the potential to modify both the pharmacokinetics and the biodistribution of encapsulated drug. Liposomes can also be designed to leak thir contents due to an increase of permeability at the temperature of the gel-liquid crystal phase transition. By this method both a selective increase of drug in tumour areas, and the positive interaction between hyperthermia and certain drugs, can be used to increase the tumour cell killing. In murine studies we have compared the plasma clearance and biodistribution by varying the formulation and size of liposomes following intraperitoneal administrationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
