The processes of bone resorption and formation are tightly gover regulatory agents. In addition, minerals and trace elements affect bone formation and resorption through direct or indirect effects on bone cells or bone mineral. Some trace elements closely chemically related to calcium, such as strontium, have pharmacological effects on bone when present at levels higher than those required for normal cell physiology. Indeed, strontium was found to exert several effects on bone cells. In addition to its antiresorptive activity, stron have significant beneficial effects on bone balance in normal and osteopenic animals. Accordingly, strontium ranelate has been thought to have potential interest in the treatment of osteoporosi aimed at designing a microfluidic device for pharmacological in individuating the concentration range in which the drug effectiveness is guaranteed. In particular, the device will be optimized for anti therapies with strontium ranelate. The device consists of a microchannel network for the delivery and mixing of chemical species, designed to provide a controlled drug concentration to the cell culture.
DESIGN OF MICROFLUIDIC DEVICES FOR DRUG SCREENING ON IN VITRO CELLS TO OPTIMIZE OSTEOPOROSIS THERAPIES
Morganti, Elisa;Tindiani, Andrea;Collini, Cristian;Ress, Cristina;Lorenzelli, Leandro;
2010-01-01
Abstract
The processes of bone resorption and formation are tightly gover regulatory agents. In addition, minerals and trace elements affect bone formation and resorption through direct or indirect effects on bone cells or bone mineral. Some trace elements closely chemically related to calcium, such as strontium, have pharmacological effects on bone when present at levels higher than those required for normal cell physiology. Indeed, strontium was found to exert several effects on bone cells. In addition to its antiresorptive activity, stron have significant beneficial effects on bone balance in normal and osteopenic animals. Accordingly, strontium ranelate has been thought to have potential interest in the treatment of osteoporosi aimed at designing a microfluidic device for pharmacological in individuating the concentration range in which the drug effectiveness is guaranteed. In particular, the device will be optimized for anti therapies with strontium ranelate. The device consists of a microchannel network for the delivery and mixing of chemical species, designed to provide a controlled drug concentration to the cell culture.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
