Microfluidics is a field that provides tools and concepts for elaborating complex lab-on-a-chip devices. The integration of actuators on the chip is a crucial issue, since it is difficult to control many independent fluid channels by a few external devices. From this standpoint, polydimethylsiloxane (PDMS) is an advantageous material, because active elements, such as valves and pumps, can be easily integrated thanks to its elastomeric properties. Active components can be fabricated using multilayer soft lithography technique. Valves are formed at the intersection between a fluidic channel and a control channel located in two separate layers. When pressure is increased in the control channel (e.g. injecting air) the membrane separating the two channels deflects and closes the fluidic channel, blocking the flow inside. Assembling three valves in series, one can fabricate peristaltic pumps. This micropump was designed to be integrated in a micro analysis system for protein assays. The designed actuator, in combination with two one-shot micropumps and a set of microvalves, will provide the entire fluidic control for biological tests.

DEVELOPMENT OF A PDMS PERISTALTIC MICROPUMP FOR MICRO ANALYSIS SYSTEMS IN PROTEIN ASSAYS

Morganti, Elisa;Collini, Cristian;Lorenzelli, Leandro;
2010

Abstract

Microfluidics is a field that provides tools and concepts for elaborating complex lab-on-a-chip devices. The integration of actuators on the chip is a crucial issue, since it is difficult to control many independent fluid channels by a few external devices. From this standpoint, polydimethylsiloxane (PDMS) is an advantageous material, because active elements, such as valves and pumps, can be easily integrated thanks to its elastomeric properties. Active components can be fabricated using multilayer soft lithography technique. Valves are formed at the intersection between a fluidic channel and a control channel located in two separate layers. When pressure is increased in the control channel (e.g. injecting air) the membrane separating the two channels deflects and closes the fluidic channel, blocking the flow inside. Assembling three valves in series, one can fabricate peristaltic pumps. This micropump was designed to be integrated in a micro analysis system for protein assays. The designed actuator, in combination with two one-shot micropumps and a set of microvalves, will provide the entire fluidic control for biological tests.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11582/10039
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